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. 2021 May 3;49(9):5106–5123. doi: 10.1093/nar/gkab313

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 7. — HDAC3 functions as a SOX30 coactivator in testes. (A) 315 genes out of 364 downregulated genes upon Sox30 KO were also downregulated in Stra8-cre/Hdac3^fl/– at the pachytene spermatocyte stage. (B) Among 722 downregulated genes in Sox30 KO at RS stage, 454 genes were also downregulated in Stra8-cre/Hdac3^fl/–. (C) Gene ontology analysis of the co-target genes downregulated in both Sox30 KO and Stra8-cre/Hdac3^fl/- at PS stage. (D) Genome browser tracks showing HDAC3 ChIP-seq and SOX30 ChIP-seq in wild-type and Sox30 KO testes at P20-P21. (E) Luciferase reporter assay showing HDAC3 co-activates the SOX30 transcriptional activity on the Nkapl promoter. (F, G) H&E staining of testes from Sox30 KO mice at 8-week-old. Arrowheads indicate multinucleated cells, and arrows point to aberrant metaphase cells. (H) Summary model for the regulatory roles of SOX30/HDAC3 signaling during meiotic exit.