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. 2021 May 1;49(9):5189–5201. doi: 10.1093/nar/gkab306

Figure 4.

Figure 4.

Effect of G4 ligand 360B and BG4 antibody on G4 folding and persistence times. (A) Folding and persistence times of 21-CTA telomeric G4 with increasing concentration of the small ligand 360B. (B) Folding and persistence times of 21-CTA G4 with increasing concentration of BG4 antibody. (C) Folding and unfolding rates of the 21-CTA G4. Fitting equations of the experimental data are displayed. (D) Schematic diagram showing the effect of a G4 binder on both folding and unfolding rates of G4 embedded in dsDNA. G4 ligand and antibody (green ellipse) may favor the folding as well as the persistence of G4.

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