Table 1. Metabolite changes predicted by the model in comparison to corresponding values found in the literature.

Abbreviations: 5-HT, serotonin; COMT, catechol O-methyltransferase; DA, dopamine; DAT, dopamine transporter; DOPAC, 3,4-dihydroxyphenylacetic acid; HVA, homovanillic acid; MAO, monoamine oxidase; SERT, serotonin transporter; TPH2, tryptophan hydroxylase 2; VMAT2, vesicular monoamine transporter 2.

Experiment	Metabolite	Model	Literature
MAO-A/B-/-	Extracellular DA	↑34.4%	↑3.2–11.6% [34]
	Total DA	↑133%	↑12 − 200% [35,36]
	Extracellular DOPAC	↓88%	↓21–78.1% [34]
	Total DOPAC	↓70.7%	↓17 − 62% [36]
	HVA	↓64.1%	↓30 − 48% [36]
	Total 5-HT	↑34.8%	↑209–700% [35,37]
	Total 5-HIAA	↓97%	↓81.8% [38]
COMT-/-	Extracellular DA	↑10.6%	↑8.6–52% [39,40]
	Total DA	↑39.1%	↑40% [41]
	Extracellular DOPAC	↑646%	↑233–628% [39,40]
	Total DOPAC	↑318%	↑387% [39]
	HVA	↓67%	↓100% [39]
DAT-/-	Extracellular DA	↑119%	↑393% [42]
	Total DA	↓71.5%	↓96% [42]
	Total 5-HT	↑3.7%	↑3.1% [37]
SERT-/-	Extracellular 5-HT	↑369%	↑450–900% [43–45]
	Total 5-HT	↓27.4%	↓53.8–76.7% [44,45]
	Total 5-HIAA	↓74.8%	↓44.4–55.6% [44,45]
TPH2+/-	Extracellular 5-HT	↓15%	↓66.2% [46]
	Total 5-HT	↓33.7%	↓78.5% [46]
	Total 5-HIAA	↓54.3%	↓72.2% [46]
Two-fold VMAT2	Extracellular DA	↑26.3%	↑44% [32]
	Total DA	↑102%	↑21% [32]