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. 2021 Feb 11;7(3):968–978. doi: 10.1002/vms3.442

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© 2021 The Authors Veterinary Medicine and Science Published by John Wiley & Sons Ltd

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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TSG‐6 secreted from cADSC elevated the expression of COX‐2 in cancer cell lines. mRNA expression levels of COX‐2 in LMeC (a), and D17 (b) cell lines. Protein levels of COX‐2 in LMeC (c) and D17 (d) cell lines. COX‐2 mRNA and protein expression in cancer cell lines decreased significantly when they were co‐cultured with TSG‐6 targeted siRNA (siTSG‐6) transfected cADSCs. Experiments were performed in triplicate and repeated three times with similar results. Results are shown as mean ± SD (*p < .05, **p < .01, ***p < .001 by one‐way ANOVA analysis)