Table 2.
Performance of different urinary biomarkers to predict BC.
| Biomarker n° of studies (n° of pts) | Cytology n = 25 (14,375) | MCM-5 n = 3 (2147) | Microsatellite n = 3 (592) | UroVysion n = 12 (5033) | BTA stat n = 6 (999) | ImmunoCyt n = 7 (4976) | NMP-22 n = 19 (8988) |
|---|---|---|---|---|---|---|---|
| Sensitivity, % | |||||||
| Mean ± SD | 45.5 ± 23.1 | 72.8 ± 12.7 | 61.5 ± 11.1 | 64.3 ± 19.0 | 70.2 ± 5.8 | 76.4 ± 8.9 | 60.1 ± 21.0 |
| Median | 46.5 | 69.0 | 62.5 | 64.4 | 71.4 | 78.3 | 58.0 |
| Range | 9.0–88.2 | 62.5–87.0 | 50.0–72.1 | 37.0–100.0 | 61.0–78.0 | 62.0–86.8 | 16.4–100.0 |
| Specificity, % | |||||||
| Mean ± SD | 89.7 ± 13.2 | 74.0 ± 11.4 | 90.1 ± 2.6 | 88.4 ± 14.2 | 77.2 ± 6.5 | 79.0 ± 5.6 | 80.6 ± 13.6 |
| Median | 94.9 | 69.0 | 90.1 | 91.3 | 76.0 | 78.7 | 85.0 |
| Range | 41.0–100 | 65.9–87.0 | 88.2–91.9 | 48.0–100.0 | 70.6–89.1 | 72.3–86.6 | 41.3–96.6 |
| NPV, % | |||||||
| Mean ± SD | 82.6 ± 16.1 | 83.0 ± 20.0 | 86.9 ± 22.2 | 72.4 ± 24.6 | 67.9 ± 17.1 | 83.4 ± 21.4 | 82.1 ± 16.6 |
| Median | 87.6 | 93.0 | 99.4 | 77.8 | 75.4 | 94.7 | 79.9 |
| Range | 34.0–98.7 | 60–96.0 | 61.2–100.0 | 25.0–97.5 | 38.0–80.2 | 37.0–97.0 | 39.0–100.0 |
| PPV, % | |||||||
| Mean ± SD | 64.9 ± 28.5 | 52.7 ± 23.2 | 53.7 ± 43.9 | 67.7 ± 26.8 | 74.8 ± 13.1 | 57.7 ± 26.7 | 48.0 ± 29.5 |
| Median | 76.2 | 64.0 | 62.5 | 61.0 | 71.4 | 61.6 | 53.6 |
| Range | 10.0–94.9 | 26–68.2 | 6.1–92.5 | 35.5–100.0 | 58.4–89.0 | 22.0–91.0 | 7.1–92.0 |
pts = patients; SD = standard deviation.