Table 2.

Assessment of methodological quality of included studies.

RCTs evaluated by RoB 2.0
RCT [year]	Crawford [2018]	Crawford [2017]	Maghrabi [2015]
Selection bias	Low risk	Moderate risk∗	Low risk
Allocation bias	Low risk	Low risk	Low risk
Performance bias	Moderate risk†	Moderate risk†	Moderate risk†
Detection bias	Moderate risk†	Moderate risk†	Moderate risk†
Attrition bias	Moderate risk‡	Moderate risk‡	Moderate risk‡
Reporting bias	Low risk	Low risk	Low risk
Overall risk of bias	Moderate	Moderate	Moderate
Observational studies evaluated by Modified Newcastle-Ottawa Scale
Author [year]	Tangalakis [2019]	Madsen [2019]
Selection	Representativeness of exposed cohort (Maximum:★)	★	★
	Selection of non-exposed cohort (Maximum:★)	★	★
	Ascertainment of exposure (Maximum:★)	★	★
Comparability	On the basis of the design or analysis (Maximum:★★)§	★	★★
Outcome	Assessment of outcome (Maximum:★)	★	★
	Adequacy of follow up of cohort (Maximum:★)	–	★
Total score (out of 7)	★★★★★(5)	★★★★★★(6)
Power	Adequately powered	Adequately powered