Table 4.

Comparison of HLA class Ⅰ and class Ⅱ allele frequencies

	Control N=40	IAD N=17	Hypophysitis N=5
HLA-A
A2	13 (32.5%)	6 (35.3%)	1 (20%)
A11	7 (17.5%)	2 (11.8%)	1 (20%)
A24	26 (65%)	11 (64.7%)	5 (100%)
A26	5 (12.5%)	3 (17.6%)	0 (0%)
A31	12 (30%)	4 (23.5%)	0 (0%)
A33	6 (15%)	2 (11.8%)	1 (20%)
HLA-B
B7	3 (7.5%)	1 (5.9%)	0 (0%)
B13	1 (2.5%)	1 (5.9%)	0 (0%)
B35	10 (25%)	4 (23.5%)	1 (20%)
B3902	1 (2.5%)	1 (5.9%)	0 (0%)
B44	8 (20%)	2 (11.8%)	1 (20%)
B48	1 (2.5%)	1 (5.9%)	1 (20%)
B51	8 (20%)	6 (35.3%)	0 (0%)
B52	7 (17.5%)	7 (41.2%)	3 (60%)
B54	6 (15%)	3 (17.6%)	2 (40%)
B55	2 (5%)	3 (17.6%)	1 (20%)
B56	1 (2.5%)	1 (5.9%)	0 (0%)
B60	4 (10%)	0 (0%)	1 (20%)
B62	3 (7.5%)	4 (23.5%)	0 (0%)
HLA-C
Cw1	11 (27.5%)	9 (52.9%)	2 (40%)
Cw4	3 (7.5%)	1 (5.9%)	1 (20%)
Cw7	11 (27.5%)	2 (11.8%)	0 (0%)
Cw8	4 (10%)	1 (5.9%)	1 (20%)
Cw9	11 (27.5%)	5 (29.4%)	1 (20%)
Cw10	8 (20%)	1 (5.9%)	0 (0%)
Cw12	6 (15%)	7* (41.2%)	4* (80%)
Cw14	11 (27.5%)	6 (35.3%)	1 (20%)
HLA-DRB1
DR4	16 (40%)	4 (23.5%)	2 (40%)
DR8	12 (30%)	2 (11.8%)	1 (20%)
DR9	8 (20%)	5 (29.4%)	0 (0%)
DR11	3 (7.5%)	1 (5.9%)	0 (0%)
DR12	5 (12.5%)	4 (23.5%)	0 (0%)
DR13	8 (20%)	1 (5.9%)	1 (20%)
DR14	4 (10%)	3 (17.6%)	1 (20%)
DR1403	1 (2.5%)	3 (17.6%)	0 (0%)
DR15	10 (25%)	10* (58.8%)	4* (80%)
HLA-DQB1
DQ4	13 (32.5%)	5 (29.4%)	2 (40%)
DQ5	10 (25%)	2 (11.8%)	1 (20%)
DQ6	24 (60%)	11 (64.7%)	4 (80%)
DQ7	7 (17.5%)	8* (47.1%)	0 (0%)
DQ8	9 (22.5%)	1 (5.9%)	1 (20%)
DQ9	11 (27.5%)	6 (35.3%)	0 (0%)
HLA-DPB1
DPw2	21 (52.5%)	8 (47.1%)	2 (40%)
DPw3	3 (7.5%)	2 (11.8%)	1 (20%)
DPw4	11 (27.5%)	1 (5.9%)	2 (40%)
DPw5	29 (72.5%)	10 (58.8%)	2 (40%)
DPw9	5 (12.5%)	7* (41.2%)	2 (40%)
DPw13	0 (0%)	2 (11.8%)	0 (0%)
DPw14	0 (0%)	2 (11.8%)	0 (0%)
DPB1*2901	0 (0%)	1 (5.9%)	0 (0%)

*P<0.05 compared with the control group.

ACTH, adrenocorticotropic hormone; HLA, human leukocyte antigen; IAD, isolated ACTH deficiency.