Table 1.
Study patient characteristics
| Variable | Study data | N |
| Sex | ||
| Male | 698 (48.9%) | 1429 |
| Age* | 59±14 (18–87) | 1429 |
| Age group | 1429 | |
| <40 | 170 (11.9%) | |
| 41–60 | 500 (35.0%) | |
| 61–80 | 733 (51.3%) | |
| ≥81 | 26 (1.8%) | |
| Ethnicity | 1429 | |
| White or white British | 1402 (98.1%) | |
| Other† | 27 (1.9%) | |
| Body weight (kg)* | 1425 | |
| All | 82.4±19.1 (38.1–203) | |
| Male | 89.0±18.4 (53.1–203) | |
| Female | 76.1±17.7 (38.1–171) | |
| BMI (kg/m2))* | 28.7±6.0 (15.1–61.5) | 1424 |
| BMI categories | 1424 | |
| Underweight (<18.5) | 18 (1.3%) | |
| Normal (18.5–25) | 362 (25.4%) | |
| Overweight (25–30) | 557 (39.1%) | |
| Obese class I (30–35) | 299 (21.0%) | |
| Obese class II (35–40) | 115 (8.1%) | |
| Obese class III (>40) | 73 (5.1%) | |
| Waist circumference (cm)* | 1413 | |
| All | 98.1±15.5 (29–200) | |
| Male | 102.3±13.8 (69–200) | |
| Female | 94.1±16.0 (29–148) | |
| Smoking status | 1428 | |
| Non-smoker | 648 (45.4%) | |
| Ex-smoker | 594 (41.6%) | |
| Current smoker | 186 (13.0%) | |
| Alcohol intake | 1400 | |
| Non-drinker | 298 (21.3%) | |
| Drinks ≤14 units | 830 (59.3%) | |
| Drinks >14 units | 272 (19.4%) | |
| Previous alcohol excess | 617 (43.5%) | 1419 |
| AUDIT-C score | 1421 | |
| Low risk (0–4) | 828 (58.3%) | |
| High risk (5–12) | 593 (41.7%) | |
| Hypertension‡ | 480 (33.6%) | 1429 |
| Type 2 diabetes‡ | 182 (12.7%) | 1428 |
| Metabolic syndrome | 595 (45.1%) | 1320 |
| Statin | 454 (31.8%) | 1429 |
| HbA1c (mmol/mol)* | 39.8±10.4 (21–112) | 1287 |
| Elevated triglyceride >1.7 mmol/L | 262 (20.2%) | 1297 |
| Reduced HDL-cholesterol (male <1 mmol/L, female <1.3 mmol/L) | 251 (19.3%) | 1302 |
| Elevated cholesterol >5 mmol/L | 600 (46.1%) | 1302 |
| Elevated ALT >1× ULN | 152 (11.8%) | 1291 |
| Elevated AST >1× ULN | 104 (8.7%) | 1196 |
| Elevated ALP >1× ULN | 59 (4.5%) | 1321 |
| Elevated GGT >1× ULN | 168 (13.1%) | 1284 |
| FLI | 1245 | |
| Low (0–30) | 393 (31.6%) | |
| Indeterminate (30–60) | 299 (24.0%) | |
| High (≥60) | 553 (44.4%) | |
| Age-adjusted FIB-4 | 1173 | |
| Low | 849 (72.4%) | |
| Intermediate | 267 (22.8%) | |
| High | 57 (4.9%) | |
| QRISK2 ≥10% | 818 (62.3%) | 1313 |
*Mean±SD (range).
†Asian (India, Pakistan, Bangladesh), Chinese, black/African/Caribbean, mixed ethnic groups.
‡Previous diagnosis.
ALP, alkaline phosphatase; ALT, alanine transferase; AST, aspartate aminotransferase; BMI, body mass index; FIB-4, Fibrosis-4; FLI, Fatty Liver Index; GGT, gamma glutamyltransferase; HbA1c, haemoglobin A1c; HDL, high-density lipoprotein; ULN, upper limit of normal.