Table 2.
Low, intermediate, high risk FLI
| Low risk | Intermediate risk | High risk (FLI ≥60) (N=553) | P value* | |
| (FLI ≤30) | (FLI 30–60) | |||
| (N=393) | (N=299) | |||
| Age | 57±16 | 60±14 | 60±12 | <0.01 |
| Gender | <0.01 | |||
| Male | 141 (35.9%) | 159 (53.4%) | 313 (56.6%) | |
| Female | 252 (64.1%) | 140 (46.8%) | 240 (43.4%) | |
| Obesity | <0.01 | |||
| BMI <30 | 387 (98.5%) | 256 (85.6%) | 182 (32.9%) | |
| BMI ≥30 | 6 (1.5%) | 43 (14.4%) | 371 (67.1%) | |
| WC (cm) | 83.1±8.9 | 95.6±6.8 | 109.8±12.3 | <0.01 |
| Alcohol | <0.01 | |||
| Non-drinker | 65 (16.9%) | 56 (19.2%) | 143 (26.2%) | |
| Within limits | 287 (74.7%) | 211 (72.3%) | 313 (57.3%) | |
| Above limits | 32 (8.3%) | 25 (8.6%) | 90 (16.5%) | |
| Hypertension | 81 (20.6%) | 93 (31.1%) | 247 (44.7%) | <0.01 |
| Type 2 diabetes | 19 (4.8%) | 27 (9.1%) | 112 (20.3%) | <0.01 |
| Prior diagnosis of fatty liver disease (NAFLD, fatty liver disease on imaging, alcohol-related fatty liver disease) | 3 (0.8%) | 4 (1.34%) | 30 (5.43%) | <0.01 |
| Statin | 84 (21.4%) | 96 (32.1%) | 214 (38.7%) | <0.01 |
| ALT | 21.8±14.9 | 24.0±11.1 | 32.8±22.2 | <0.01 |
| Elevated ALT >1× ULN | 18 (4.7%) | 16 (5.4%) | 108 (20.0%) | <0.01 |
| AST | 25.4±11.6 | 25.8±7.9 | 30.3±17.3 | 0.07 |
| Elevated AST >1× ULN | 18 (4.9%) | 10 (3.6%) | 72 (14.0%) | <0.01 |
| GGT | 21.8±14.0 | 31.5±21.5 | 75.9±177.1 | <0.01 |
| IgA | 2.3±1.0 | 2.5±1.2 | 2.7±1.3 | <0.01 |
| Triglyceride | 0.8±0.3 | 1.1±0.4 | 1.9±1.8 | <0.01 |
| HDL-cholesterol | 1.7±0.4 | 1.5±0.4 | 1.3±0.4 | <0.01 |
| HbA1c | 37.0±7.0 | 38.8±10.3 | 42.6±12.1 | <0.01 |
| Fasting glucose | 4.8±1.1 | 5.2±2.1 | 5.9±2.0 | <0.01 |
| Age-adjusted FIB-4 risk | 0.64 | |||
| Low | 272 (74.9%) | 194 (71.6%) | 361 (70.8%) | |
| Intermediate | 77 (21.2%) | 65 (24.0%) | 121 (23.7%) | |
| High | 14 (3.9%) | 12 (4.4%) | 28 (5.5%) | |
| Elevated QRISK | 178 (46.8%) | 184 (62.4%) | 398 (72.6%) | <0.01 |
*From Χ2 test/one-way ANOVA across the three groups.
ALT, alanine transferase; ANOVA, analysis of variance; AST, aspartate aminotransferase; BMI, body mass index; FIB-4, Fibrosis-4; FLI, Fatty Liver Index; GGT, gamma glutamyltransferase; HbA1c, haemoglobin A1c; HDL, high-density lipoprotein; NAFLD, non-alcoholic fatty liver disease; ULN, upper limit of normal; WC, waist circumference.