Table 2.
Biomarker | PsA duration | Psoriasis duration | Time from psoriasis to PsA | Psoriasis BSA | Psoriasis PASI | Swollen joint count (66) | Tender joint count (68) | Das28-CRP | |
CRP | r | 0.07 | 0.01 | −0.04 | 0.11 | 0.09 | 0.12 | 0.12 | 0.39 |
p | 0.20 | 0.89 | 0.51 | 0.07 | 0.14 | 0.04 | 0.04 | <0.0001 | |
SAA | r | 0.14 | −0.03 | −0.11 | 0.12 | 0.07 | 0.14 | 0.16 | 0.35 |
p | 0.02 | 0.64 | 0.06 | 0.04 | 0.24 | 0.01 | 0.01 | <0.0001 | |
IL-17A | r | 0.14 | 0.17 | 0.10 | 0.48 | 0.48 | 0.01 | 0.04 | 0.10 |
p | 0.01 | 0.003 | 0.09 | <0.0001 | <0.0001 | 0.91 | 0.47 | 0.10 | |
IL-17F | r | 0.12 | 0.17 | 0.12 | 0.49 | 0.53 | −0.003 | 0.05 | 0.05 |
p | 0.03 | 0.004 | 0.04 | <0.0001 | <0.0001 | 0.96 | 0.37 | 0.38 | |
IL-22 | r | −0.03 | 0.12 | 0.11 | 0.46 | 0.45 | 0.08 | 0.08 | 0.14 |
p | 0.61 | 0.04 | 0.07 | <0.0001 | <0.0001 | 0.18 | 0.16 | 0.01 | |
TNFα | r | 0.11 | 0.09 | 0.03 | 0.19 | 0.23 | 0.07 | 0.12 | 0.13 |
p | 0.06 | 0.13 | 0.62 | 0.001 | <0.0001 | 0.24 | 0.04 | 0.02 | |
IL-6 | r | 0.13 | 0.01 | −0.07 | 0.08 | 0.09 | 0.15 | 0.20 | 0.36 |
p | 0.03 | 0.80 | 0.26 | 0.15 | 0.12 | 0.01 | 0.001 | <0.0001 | |
IFN-γ | r | 0.04 | −0.03 | −0.04 | 0.09 | 0.09 | 0.06 | 0.06 | 0.08 |
p | 0.53 | 0.57 | 0.47 | 0.12 | 0.13 | 0.32 | 0.31 | 0.14 | |
sICAM-1 | r | 0.04 | 0.12 | 0.09 | 0.09 | 0.10 | 0.06 | 0.09 | 0.15 |
p | 0.47 | 0.05 | 0.13 | 0.10 | 0.10 | 0.30 | 0.11 | 0.01 | |
sVCAM-1 | r | 0.08 | 0.06 | 0.01 | 0.01 | 0.00004 | 0.004 | 0.04 | 0.08 |
p | 0.15 | 0.28 | 0.81 | 0.88 | 1.0 | 0.94 | 0.47 | 0.19 | |
CCL2 (MCP-1) | r | 0.09 | 0.13 | 0.06 | 0.17 | 0.13 | 0.19 | 0.17 | 0.18 |
p | 0.12 | 0.02 | 0.28 | 0.003 | 0.03 | 0.001 | 0.003 | 0.002 | |
CCL22 (MDC) | r | 0.01 | 0.06 | 0.08 | 0.37 | 0.37 | 0.08 | 0.04 | 0.07 |
p | 0.90 | 0.30 | 0.19 | <0.0001 | <0.0001 | 0.17 | 0.46 | 0.22 | |
CCL4 (MIP-1β) | r | 0.02 | −0.01 | −0.01 | −0.03 | −0.06 | −0.06 | −0.06 | −0.06 |
p | 0.73 | 0.80 | 0.90 | 0.57 | 0.32 | 0.30 | 0.31 | 0.31 | |
IL-8 | r | −0.02 | 0.04 | 0.07 | 0.16 | 0.2 | 0.12 | 0.09 | 0.13 |
p | 0.67 | 0.44 | 0.26 | 0.004 | 0.001 | 0.04 | 0.13 | 0.02 | |
YKL-40 | r | 0.14 | 0.11 | 0.04 | 0.14 | 0.13 | 0.12 | 0.16 | 0.31 |
p | 0.02 | 0.06 | 0.52 | 0.02 | 0.02 | 0.03 | 0.007 | <0.0001 |
Significance is defined by p<0.05 and fold change ≥1.4 (shown in bold).
BSA, body surface area; CRP, C reactive protein; DAS28, 28 joint Disease Activity Score; IFN γ, interferon γ; IL, interleukin; PASI, Psoriasis Area and Severity Index; PsA, psoriatic arthritis; r, correlation coefficient; SAA, serum amyloid A; TNF, tumour necrosis factor.