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. 2021 May 6;12:647304. doi: 10.3389/fmicb.2021.647304

FIGURE 2.

FIGURE 2

Gastrointestinal dysfunction after ICH. (A) Intestinal motility was measured 3 days after sham and ICH surgery. Representative fluorescence images of the complete gastrointestinal tract 1 h after gastric instillation of FITC-dextran showing retention of the fluorescence intensity in intensity segments after ICH. (B) Quantification of fluorescent intensity in intestinal segments (n = 6 per group). (C) Intestinal permeability was measured by oral gavage of FITC-dextran (4 KD) with subsequent analysis of the level plasma of FITC-dextran. There was a significant increase in the ICH mice than the sham group after 3 days. (n = 6 per group). (D) Intestinal histopathologic changes after ICH 3, 7, and 14 days of ICH. Hematoxylin and eosin staining shows thinning of the layers of epithelium and muscularis mucosae; loss of crypts and glands; edema of the lamina propria; and thickened and shortened villi at the histomorphometric level (n = 3 per group). Data are expressed as the mean ± standard error of the mean. ***P < 0.001 vs. sham group.