Table 1.
Baseline characteristics according to nonalcoholic fatty liver disease status
| Characteristic | Total (n = 6,182) | NAFLD (–) (n = 3,540) | NAFLD (+) (n = 2,642) | p value | ||
|---|---|---|---|---|---|---|
| Men | 4,659 | 2,328 | 2,331 | |||
| Age, yr | 43.3 ± 8.2 | 43.3 ± 8.5 | 43.3 ± 7.9 | 0.967 | ||
| Current or former smoking, % | 63.7 | 62.0 | 65.5 | 0.015 | ||
| Family history of CRC, % | 6.3 | 6.3 | 6.3 | 0.991 | ||
| Use of NSAIDs, % | 3.2 | 3.0 | 3.4 | 0.364 | ||
| BMI, kg/m2 | 24.7 ± 2.9 | 23.4 ± 2.4 | 26.0 ± 2.7 | < 0.001 | ||
| Obesity, BMI ≥ 25 kg/m2, % | 43.3 | 23.8 | 62.8 | < 0.001 | ||
| Regular exercisea, % | 13.7 | 15.8 | 11.6 | < 0.001 | ||
| Baseline adenoma characteristics | 0.082 | |||||
| Low-risk adenoma, % | 83.9 | 84.9 | 83.0 | |||
| High-risk adenoma, % | 16.1 | 15.1 | 17.0 | |||
| Interval between index and follow-up colonoscopy, yr | 3.5 ± 1.4 | 3.5 ± 1.4 | 3.5 ± 1.4 | 0.762 | ||
| Women | 1,523 | 1,212 | 311 | |||
| Age, yr | 44.7 ± 8.8 | 43.6 ± 8.3 | 48.9 ± 9.4 | < 0.001 | ||
| Current or former smoking, % | 4.5 | 4.4 | 5.1 | 0.559 | ||
| Family history of CRC, % | 6.6 | 6.6 | 6.8 | 0.924 | ||
| Use of NSAIDs, % | 4.8 | 4.7 | 5.1 | 0.745 | ||
| BMI, kg/m2 | 22.6 ± 3.2 | 21.8 ± 2.5 | 25.9 ± 3.5 | < 0.001 | ||
| Obesity, BMI ≥ 25 kg/m2, % | 18.7 | 9.0 | 56.6 | < 0.001 | ||
| Regular exercisea, % | 17.9 | 18.0 | 17.2 | 0.748 | ||
| Baseline adenoma characteristics | 0.114 | |||||
| Low-risk adenoma, % | 83.1 | 83.8 | 80.1 | |||
| High-risk adenoma, % | 16.9 | 16.2 | 19.9 | |||
| Interval between index and follow-up colonoscopy, yr | 3.4 ± 1.4 | 3.5 ± 1.4 | 3.3 ± 1.3 | 0.027 | ||
Values are presented as mean ± standard deviation.
NAFLD, nonalcoholic fatty liver disease; CRC, colorectal cancer; NSAIDs, nonsteroidal anti-inflammatory drugs; BMI, body mass index.
a
Moderate or vigorous physical activity ≥ 3 times per week.