Table 2.
Risk factors for metachronous overall colorectal neoplasia
| Variable | Crude HR (95% CI) |
Adjusted HR (95% CI)a |
||
|---|---|---|---|---|
| Men | Women | Men | Women | |
| NAFLD | ||||
| No | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) |
| Yes | 1.18 (1.07–1.29) | 1.99 (1.59–2.50) | 1.17 (1.06–1.29) | 1.63 (1.27–2.07) |
| Age, yr | 1.04 (1.03–1.04) | 1.05 (1.04–1.06) | 1.04 (1.03–1.04) | 1.04 (1.03–1.05) |
| Current or former smoking | 1.08 (0.98–1.19) | 0.92 (0.56–1.51) | 1.06 (0.96–1.18) | 0.88 (0.53–1.45) |
| Family history of CRC | 1.32 (1.09–1.59) | 1.27 (0.86–1.87) | 1.22 (1.01–1.48) | 1.24 (0.83–1.85) |
| Use of NSAIDs | 1.10 (0.85–1.42) | 0.89 (0.54–1.47) | 1.04 (0.80–1.35) | 0.87 (0.52–1.46) |
| Regular exerciseb, % | 1.03 (0.90–1.18) | 1.07 (0.80–1.43) | 0.94 (0.81–1.08) | 0.99 (0.74–1.33) |
| Baseline adenoma characteristics | ||||
| Low-risk adenoma | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) |
| High-risk adenoma | 1.57 (1.40–1.77) | 1.58 (1.21–2.05) | 1.40 (1.24–1.59) | 1.28 (0.97–1.68) |
HR, hazard ratio; CI, confidence interval; NAFLD, nonalcoholic fatty liver disease; CRC, colorectal cancer; NSAID, nonsteroidal anti-inflammatory drug.
a
Values were adjusted for NAFLD, age, current or former smoking, family history of CRC, use of NSAIDs, regular exercise, and baseline adenoma characteristics.
b
Moderate or vigorous physical activity ≥ 3 times per week.