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. 2021 Feb 26;101(6):680–689. doi: 10.1038/s41374-021-00538-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Time course recording of the current increases induced by CAP (10 µmol/l) and declined after application of 1 mmol/l L-carnitine. B Original traces of CAP-induced current responses to voltage ramps. Current densities are shown before application (labeled as A), during application of 10 µmol/l CAP (labeled as B) and after addition of 1 mmol/l L-carnitine (labeled as C). Calculated current densities obtained by normalizing currents to membrane capacitance as function of imposed voltage were derived from the traces shown in A. C Summary of patch-clamp experiments with CAP and L-carnitine. The asterisks (*) indicate statistically significant differences of whole-cell currents with and without CAP (n = 7; p < 0.05; paired tested) and significant difference of CAP-induced increased with and without L-carnitine (n = 7; p < 0.05; paired tested). D Maximal negative current amplitudes induced by a voltage step from 0 to −60 mV are depicted in percent of control values before application of 10 l/l CAP (control set to 100%). CAP-induced inward currents could be clearly suppressed in the presence of 1 mmol/l L-carnitine. E Same diagram but related to maximal positive current amplitudes induced by a voltage step from 0 to +130 mV.