Table 2.
Blood lipid and oxLDL concentrations at baseline, after 4 weeks, and after 8 weeks of supplementation
| Placebo | OLE | Uncorrected p1 | Uncorrected p2 | |||||
|---|---|---|---|---|---|---|---|---|
| Baseline | 4 weeks | 8 weeks | Baseline | 4 weeks | 8 weeks | |||
| Total cholesterol (mmol/L) | 5.8 ± 0.1 | 5.7 ± 0.1 | 5.7 ± 0.1 | 6.1 ± 0.1 | 6.0 ± 0.1 | 6.0 ± 0.1 | 0.472 | 0.838 |
| HDL-cholesterol (mmol/L) | 1.6 ± 0.1 | 1.6 ± 0.1 | 1.6 ± 0.1 | 1.7 ± 0.1 | 1.7 ± 0.1 | 1.6 ± 0.1 | 0.575 | 0.490 |
| Non-HDL-cholesterol (mmol/L) | 4.1 ± 0.1 | 4.1 ± 0.1 | 4.0 ± 0.1 | 4.4 ± 0.1 | 4.3 ± 0.1 | 4.3 ± 0.1 | 0.586 | 0.960 |
| LDL-cholesterol (mmol/L) | 3.6 ± 0.1 | 3.5 ± 0.1 | 3.5 ± 0.1 | 3.8 ± 0.1 | 3.7 ± 0.1 | 3.8 ± 0.1 | 0.802 | 0.571 |
| Triglycerides (mmol/L) | 1.2 ± 0.1 | 1.3 ± 0.1 | 1.3 ± 0.1 | 1.3 ± 0.1 | 1.2 ± 0.1 | 1.2 ± 0.1 | 0.028a | 0.176 |
| Total cholesterol/HDL-cholesterol | 3.8 ± 0.2 | 3.8 ± 0.2 | 3.7 ± 0.2 | 3.9 ± 0.2 | 3.8 ± 0.2 | 3.9 ± 0.2 | 0.501 | 0.852 |
| Triglycerides/HDL-cholesterol | 0.8 ± 0.1 | 0.9 ± 0.1 | 0.9 ± 0.1 | 0.9 ± 0.1 | 0.8 ± 0.1 | 0.9 ± 0.1 | 0.018a | 0.155 |
| OxLDL (U/L) | 72.8 ± 2.8 | 73.1 ± 2.9 | 73.9 ± 3.1 | 83.6 ± 2.9 | 82.3 ± 2.9 | 83.3 ± 3.0 | 0.595 | 0.613 |
All values are presented as mean ± SEM. Differences between the placebo and OLE were compared with an unstructured linear mixed model with correction for baseline values. p1 and p2 represent the p values for the difference in estimated means after 4 and 8 weeks of intervention, respectively, between placebo and OLE, corrected for baseline differences
HDL high-density lipoprotein, LDL low-density lipoprotein, OxLDL oxidized low-density lipoprotein, OLE olive leaf extract
ap > 0.05 after correction for multiple testing by the false-discovery rate (FDR) of Benjamini–Hochberg (16 tests)