Table 1.
Neuropsychological performance at ages 47 and 49 (14 months apart)
| Cognitive Test Scores | Age 47 | Age 49 | Normative Reference* | ||
|---|---|---|---|---|---|
| M (SD) | Mdn (IQR) | ||||
| Global | CDR | ||||
| Global | 0.5 | 1.0 | - | - | |
| Sum of Boxes | 4.0 | 7.0 | - | - | |
| Behavior | 2.0 | 3.0 | - | - | |
| Language | 0.5 | 1.0 | - | - | |
| MMSE | 26 | 22 | 29.2 (1.0) | 29 (29, 30) | |
| Memory | CVLT-SF (9-word list) | ||||
| Immediate Recall (T1-T4) | 18 | 15 | 28.9 (3.1) | 29 (27, 32) | |
| 30” Delay | 6 | 5 | 7.7 (1.3) | 8 (7, 9) | |
| 10’ Delay | 7 | 5 | 7.2 (1.5) | 7.5 (6, 8) | |
| Recognition (d’) | 3.5 | 1.5 | 3.1 (0.5) | - | |
| Benson Figure | |||||
| 10’ Delay | 13 | 15 | 12.7 (2.4) | 13 (11, 14) | |
| Recognition | Correct | Correct | - | ||
| Executive Function | Digit Span | ||||
| Forward | 5 | 4 | 7.3 (1.2) | 7 (6, 8) | |
| Backward | 3 | 3 | 5.7 (1.3) | 6 (5, 7) | |
| Modified Trails | |||||
| Correct Lines (max=14) | 14 | 5 | - | - | |
| Time” (max=120”) | 25” | 120” | 24.2 (10.3) | 22 (17, 29) | |
| Errors | 1 | 12 | - | - | |
| Design Fluency (designs/min) | |||||
| Total Correct | 4 | 2 | 12.6 (3.4) | 12 (10, 15) | |
| Repetition Errors | 7 | 17 | - | ||
| D-Words (words/min) | |||||
| Total Correct | 4 | 3 | 15.9 (4.6) | 16 (13, 19) | |
| Errors | 1 | 7 | - | - | |
| Animal Fluency (words/min) | |||||
| Total Correct | 9 | 6 | 24.0 (5.7) | 24 (20, 28) | |
| Errors | 0 | 3 | - | - | |
| Spatial/Construction | MMSE Pentagons | Correct | Incorrect | - | |
| Benson Figure Copy | 16 | 14 | 15.6 (0.9) | 16 (15, 16) | |
| VOSP Number Location | 10 | 8 | 9.4 (0.9) | 10 (9, 10) | |
| Language | WRAT-4 Word Reading | 63 | 61 | 64.1 (3.3) | 65 (61, 67) |
| BNT-15 | 15 | 15 | 14.1 (1.1) | 15 (14, 15) | |
| PPVT (max=16) | 16 | 15 | - | - | |
| Comprehension (max=5) | 5 | 2 | - | - | |
| Repetition (max=5) | 5 | 4 | - | - | |
| Verbal Agility (max=6) | 6 | 3 | - | - | |
*
Normative reference values derived from a cohort of demographically-matched, cognitively healthy adults: (N=74–100 across tests, age=48.2±9.2 years old, education=17.0±2.3 years, 100% male, 100% white/Caucasian). Both mean±SD [M (SD)] and median with interquartile range [Mdn (IQR)] are provided where possible.
*
Additional phrase repetition testing performed during the second evaluation
| Prompt | Patient Response |
|---|---|
| The cat ate the caterpillar | “Cat ate the cata-pilla” |
| Justin is taller than Henry | “Justin is taller than He-ry” |
| A teacher bought three pairs of gloves | “Peacher bought three pairs of gloves” |
| We walked to the lake and then to the store | “We walked to the lake and then to the store” |
| The rabbit was given to the child by a fireman | “Rabbit was given to the child by a fireman” |