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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: Liver Int. 2021 Feb 16;41(6):1305–1319. doi: 10.1111/liv.14811

Figure 5. The maternal HF diet resulted in genomic hypermethylation in offspring livers, and was associated with the overactivation of DNA methyl transferase (DNMT), while the H9N diet had no significant effect.

Figure 5.

5A. The enzymatic activity of SAM dependent methyltransferases was determined in male offspring. 5B. The enzymatic activity of DNMT was determined in male offspring. 5C. Hepatic gene expression levels of Dnmt1, Dnmt3a and Dnmt3b in male offspring were measured by real-time PCR. 5D. Genomic DNA methylation levels were determined in the male offspring livers. 5E. Hepatic gene expression levels of Dnmt1, Dnmt3a and Dnmt3b in female offspring were measured by real-time PCR. 5F. Genomic DNA methylation levels were determined in female offspring livers.Data are presented as the mean ± SE, n=5. * indicates P<0.05 vs. NF group. # indicates P<0.05 vs. the REF group.