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. Author manuscript; available in PMC: 2021 Oct 15.
Published in final edited form as: Cancer Res. 2021 Feb 8;81(8):1942–1953. doi: 10.1158/0008-5472.CAN-20-2769

Figure 1. miR-31 is overexpressed in specific histological subtypes of lung cancer.

Figure 1.

(A) IHC of patient tumors from each histological subtype with markers of each (10X) and ISH of miR-31 (100X), depicting overexpression of miR-31 in LUAD, SQCC, ADSQ, and LCNEC but not in SCLC. TTF-1 is a marker of LUAD, p63 of SQCC, and synaptophysin (SYN) of neuroendocrine carcinomas. (B-C) miR-31 levels determined with Taqman qRT-PCR. Expression normalized to endogenous control RNU6B. (B) Archived patient tissue from 2016-2019 of normal, LUAD, SQCC, ADSQ, LCNEC, SCLC, and atypical carcinoid (AC) lung tumors. (C) Cell lines. Mean miR-31 expression (Error bars ± SEM: *p<0.05, student’s t-test). Number (n) samples indicated.