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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Biophys Chem. 2021 Apr 20;274:106590. doi: 10.1016/j.bpc.2021.106590

Figure 5. Crosslinks mapped to cryo-EM structural model of the CYP102A1 homodimer in Closed (A and C) and Open II (B and C) conformations.

Figure 5.

Since the dimer is not symmetrical, we arbitrary labeled one monomer α (light grey) and the other β (dark grey). The heme-containing oxygenase (BMP) and flavin-containing reductase (BMR) domains of each monomer are labeled accordingly. Cofactors and crosslinks are colored as in Figure 3. 27Å scale bar indicates the accepted Cα-Cα distance restraint for the DSBU crosslinker. Crosslinks #1–8 with the exception of #6 from Table 5 are shown in A and B. Crosslinks #9–19 from Table 5 are shown in C and D.