Table 2.
Adjusted means (SD) of normalized abundances over three groups of the exposures for those bacteria with P-trend < 0.05 over those three exposure groups
| Model 1 | Model 2 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Added sugar | < 10E% | 10-20E% | > 20E% | ß-trend | P-trend | P’-trend | Added sugar | < 10E% | 10-20E% | > 20E% | ß-trend | P-trend | P’-trend |
| n = 1371 | 455 | 780 | 136 | n = 1371 | 455 | 780 | 136 | ||||||
| Streptococcus | 7.72 (0.13) | 8.08 (0.10) | 8.66 (0.25) | 0.05 | 0.001 | 0.060 | Streptococcus | 7.75 (0.14) | 8.07 (0.10) | 8.56 (0.26) | 0.05 | 0.005 | 0.314 |
| Oxalobacter | 2.81 (0.19) | 2.32 (0.12) | 2.10 (0.28) | – 0.16 | 0.015 | 0.355 | Succiniclasticum | 0.19 (0.09) | 0.06 (0.02) | 0.06 (0.05) | – 0.81 | 0.029 | 0.518 |
| Paraprevotella | 4.03 (0.29) | 3.19 (0.17) | 3.21 (0.41) | – 0.16 | 0.019 | 0.355 | Paraprevotella | 4.00 (0.29) | 3.19 (0.17) | 3.29 (0.43) | –0.14 | 0.036 | 0.518 |
| Lachnobacterium | 4.13 (0.10) | 4.03 (0.07) | 3.60 (0.17) | –0.05 | 0.025 | 0.355 | Oxalobacter | 2.77 (0.19) | 2.33 (0.12) | 2.19 (0.30) | –0.14 | 0.038 | 0.518 |
| Odoribacter | 2.01 (0.16) | 1.88 (0.11) | 1.26 (0.19) | –0.17 | 0.033 | 0.355 | Odoribacter | 2.02 (0.16) | 1.88 (0.11) | 1.27 (0.20) | –0.17 | 0.040 | 0.518 |
| Succiniclastisum | 0.17 (0.07) | 0.06 (0.02) | 0.06 (0.05) | –0.74 | 0.033 | 0.355 | |||||||
| PC added × U-sugars | T1 | T2 | T3 | ß-trend | P-trend | P’-trend | PC added × U-sugars | T1 | T2 | T3 | ß-trend | P-trend | P’-trend |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n = 577 | 193 | 192 | 192 | n = 577 | 193 | 192 | 192 | ||||||
| Odoribacter | 2.15 (0.24) | 2.37 (0.26) | 1.36 (0.16) | –0.22 | 0.012 | 0.507 | Odoribacter | 2.13 (0.24) | 2.34 (0.26) | 1.39 (0.17) | –0.21 | 0.020 | 0.822 |
| Streptococcus | 7.89 (0.21) | 8.56 (0.21) | 8.64 (0.22) | 0.05 | 0.016 | 0.507 | Succiniclasticum | 0.26 (0.16) | 0.11 (0.05) | 0.05 (0.03) | –0.79 | 0.032 | 0.822 |
| Succiniclasticum | 0.25 (0.14) | 0.11 (0.06) | 0.05 (0.03) | –0.78 | 0.024 | 0.507 | Lactobacillus | 2.43 (0.19) | 2.84 (0.21) | 3.08 (0.24) | 0.12 | 0.039 | 0.822 |
| Lactobacillus | 2.44 (0.19) | 2.85 (0.21) | 3.06 (0.23) | 0.11 | 0.044 | 0.711 |
| SSBs | Non | Medium | High | ß-trend | P-trend | P’-trend | SSBs | Non | Medium | High | ß-trend | P-trend | P’-trend |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n = 1086 | 314 | 425 | 347 | n = 1086 | 314 | 425 | 347 | ||||||
| Lachnobacterium | 4.23 (0.13) | 4.12 (0.10) | 3.61 (0.11) | –0.08 | 0.0003* | 0.020 | Lachnobacterium | 4.19 (0.13) | 4.11 (0.10) | 3.65 (0.11) | –0.07 | 0.002 | 0.088 |
| Dialister | 8.04 (0.28) | 9.05 (0.25) | 9.35 (0.30) | 0.07 | 0.003 | 0.090 | Dialister | 8.04 (0.30) | 9.05 (0.25) | 9.35 (0.30) | 0.07 | 0.003 | 0.088 |
| Lactobacillus | 2.36 (0.15) | 2.74 (0.14) | 3.04 (0.19) | 0.13 | 0.007 | 0.111 | Lactobacillus | 2.33 (0.15) | 2.73 (0.14) | 3.09 (0.19) | 0.14 | 0.004 | 0.088 |
| [Eubacterium] | 5.12 (0.21) | 5.53 (0.18) | 6.00 (0.23) | 0.08 | 0.007 | 0.111 | Cetobacterium | 0.16 (0.27) | 0.02 (0.02) | 0.004 (0.004) | –1.84 | 0.044 | 0.607 |
| Roseburia | 9.20 (0.18) | 9.16 (0.15) | 8.58 (0.17) | –0.04 | 0.016 | 0.208 | |||||||
| Anaerotruncus | 2.16 (0.13) | 2.48 (0.12) | 2.66 (0.15) | 0.10 | 0.021 | 0.222 | |||||||
| Unknown genus in the Peptostreptococceae family | 6.20 (0.15) | 6.56 (0.13) | 6.68 (0.15) | 0.04 | 0.039 | 0.353 |
| ASBs | Non | Medium | High | ß-trend | P-trend | P’-trend | ASBs | Non | Medium | High | ß-trend | P-trend | P’-trend |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n = 1085 | 669 | 269 | 147 | n = 1085 | 669 | 269 | 147 | ||||||
| Prevotella | 6.01 (0.17) | 6.82 (0.29) | 7.20 (0.42) | 0.10 | 0.001 | 0.075 | Prevotella | 6.04 (0.17) | 6.78 (0.29) | 7.12 (0.42) | 0.09 | 0.004 | 0.257 |
| Unknown genus in the RF16 family | 1.81 (0.12) | 2.32 (0.24) | 2.56 (0.35) | 0.19 | 0.007 | 0.234 | Unknown genus in the RF16 family | 1.82 (0.12) | 2.30 (0.23) | 2.50 (0.34) | 0.18 | 0.017 | 0.525 |
| Sutterella | 3.49 (0.15) | 4.44 (0.31) | 4.16 (0.39) | 0.12 | 0.013 | 0.265 | Sutterella | 3.51 (0.16) | 4.40 (0.30) | 4.12 (0.39) | 0.11 | 0.025 | 0.525 |
| Unknown genus in the SHA98 order | 2.78 (0.15) | 2.40 (0.22) | 2.06 (0.25) | –0.15 | 0.017 | 0.265 | Lachnospira | 5.86 (0.10) | 5.67 (0.15) | 5.40 (0.20) | –0.04 | 0.037 | 0.588 |
| [Eubacterium] | 5.32 (0.14) | 5.99 (0.24) | 5.90 (0.33) | 0.07 | 0.021 | 0.268 | |||||||
| Unknown genus in the Christensenellaceae family | 4.31 (0.10) | 4.21 (0.15) | 3.79 (0.19) | –0.05 | 0.032 | 0.296 | |||||||
| Lachnospira | 5.86 (0.09) | 5.68 (0.15) | 5.40 (0.19) | –0.04 | 0.032 | 0.296 |
PC added × U-sugars is divided into equal tertiles. SSBs and ASBs are combinations of 4DFR and FFQ and are divided into three groups according to Fig. 1. Negative binomial regressions were used. Model 1 is adjusted for age, sex, energy intake, smoking and PAL. Model 2 is additionally adjusted for fiber intake and BMI
*Holds after FDR correction. P’ is adjusted for FDR using the Benjamini–Hochberg method