Fig. 1.

Effects of tested urolithins and respective glucuronides at the concentration of 40 μM on LPS-induced TNF-α and IL-10 production. PMA-differentiated THP-1 cells were preincubated for 1 h with iso-urolithin A, urolithin A and B (iUA, UA, UB) and their respective glucuronides (GiUA, GUA, GUB) at the concentration of 40 μM and stimulated with LPS (10 ng/mL). Statistical significance: *p < 0.05, **p < 0.001 decrease versus stimulated control (Dunnettʼs post hoc test); ^#p < 0.05, ^##p < 0.001 increase versus stimulated control; LPS—stimulated control; NST—non-stimulated control. Parth-parthenolide at the concentration of 5 μM (positive control). Data are expressed as mean ± SD of three separate experiments performed in triplicate. Mean ± SD and p values are provided in Supplementary material Table S3