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. 2021 May 20;12:2965. doi: 10.1038/s41467-021-23324-4

Fig. 6. Accurate classification of human TIL states by projecting cancer patient transcriptomes on a reference mouse atlas.

Fig. 6

a scRNA-seq data from patients’ biopsies were analyzed using ProjecTILs in human-mouse orthology mode. Below, UMAP projection for TILs from one subject, colored by annotation according to Li et al. Projections for other subjects are available in Supplementary Fig. 9. b Fraction of cells classified in different subtypes by ProjecTILs compared to main original annotations by Yost et al. or Li et al. (complete annotation in Supplementary Fig. 10). c UMAP projections of cell subsets defined according to TIL state annotations by Yost et al. (e.g. exhausted, effector) or Li et al. (e.g. dysfunctional, cytotoxic). Radar plots display representative expression profiles of cells classified in the reference states for T cell marker genes. BC carcinoma basal cell carcinoma.