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. 2021 May 20;12:2965. doi: 10.1038/s41467-021-23324-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a ProjecTILs projections and predicted subtype frequencies in biopsies from different tissues: blood, metastatic lymph nodes (mLN) and tumors (data from Li et al. cohort). b Subtype composition bias (fold change) in tumors vs mLN. c Frequency of cells from the top 10 expanded clonotypes over the total number of cells in each subtype. d–e The upper panels (heatmaps) display Morisita similarity indices measuring TCR repertoire overlap for each pair of TIL subtypes in the Li et al. (d) and Yost et al. (e) cohorts. Bottom panels: projection of TIL clones for the top three expanded clonotypes enriched in Tex or Tpex subtypes in each patient cohort. f Average normalized gene expression of human T cells projected in the CD8⁺ NaiveLike, CD8⁺ Effector Memory (CD8_EM), CD8⁺ Tpex and CD8⁺ Tex subtypes for a panel of key marker genes.