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Weak positive reaction at 48 and 96 h. a At 48 h, palpable erythema (arrow) is noted on the upper back located at the site of nickel sulfate hexahydrate Finn Chambers AQUA® (Smart Practice, Phoenix, Arizona, US) system occlusion. b At 96 h, the erythema and infiltration (arrow) have spread to all skin contacted by nickel sulfate hexahydrate. According to International contact dermatitis research group criteria, this patch test was read as 1+
