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. 2021 May 7;13:668775. doi: 10.3389/fnagi.2021.668775

FIGURE 2.

FIGURE 2

Supplementation of AP-32, RM, and A-RM rescued the 6-OHDA-mediated reduction of dopaminergic neurons in the striatum and substantia nigra pars compacta (SNc) after 8-weeks of supplementations. (A) A representative of the immunohistochemical staining for TH (dopaminergic neuron marker) in the striatum. (B) Quantitative analysis of the number of TH-positive cells in the striatum. (C) A representative of the immunohistochemical staining for TH in SNc. (D) Quantitative analysis of the number of TH-positive cells in the SNc. The intensity of the lesioned side was standardized with the non-lesioned side and reported as mean ± SEM (n = 5 rats/group). #p < 0.05 PD group compared to NC group. *p < 0.05 L, AP-32, RM, and A-RM groups compared to PD group. Data were evaluated by one-way ANOVA with Tukey’s post hoc test.