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. 2021 May 7;12:635267. doi: 10.3389/fimmu.2021.635267

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Copyright © 2021 Gu, Hu, Ge, Chen, Wu and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CTRP1 increases the interaction between adiponectin receptor 1 and TLR4. (A) The expression levels of Adipo R1, Adipo R2 and TLR4 in bone marrow-derived macrophages isolated from CTRP1 -/- mice as well as WT mice treated with CTRP1 in vitro. (B) Bone marrow-derived macrophages were cotransfected with psicoR-HA-TLR4 and psicoRFlag-CTRP1, and a coimmunoprecipitation experiment was performed. (C) Bone marrow-derived macrophages were cotransfected with psicoR-HA-TLR4 and psicoRFlag-Adipo R1, and a coimmunoprecipitation experiment was performed. *P<0.05. All in vitro experiments were repeated 3 times.