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TLR4 knockout counteracts the effects of CTRP1 in vivo. (A) The survival rate of TLR4 knockout mice receiving the human recombinant CTRP1 protein at 28 days post MI (n=30 per group). (B) TTC staining and quantification of the infarct area (n=6). (C) Heart, body, and lung weights of mice at 28 days post MI (n=12). (D) Echocardiography of mice at 28 days post MI (n=10). (E) Inflammatory cytokine levels in heart tissue post MI (n=6). *P<0.05 vs. the WT-VEH group. NS, not significant.
