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. 2021 May 7;12:672205. doi: 10.3389/fphys.2021.672205

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Copyright © 2021 Awais, Shakeel and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A typical model for miRNA biogenesis. RNA polymerase II(RNA pol II), transcribing miRNA gene into a hair-loop structure known as the pri-miRNA. The Drosha/Pasha microprocessor complex process pri-miRNA to pre-miRNA in the nucleus. The pre-miRNA is exported into the cytoplasm in a RanGTP/Exp-5 dependent manner. The pre-miRNA is processed by Dicer-1 (Dcr-1) and Loquacious (Loqs) to form the miRNA-miRNA* duplex within the cytoplasm. The duplex strands are then sorted, and the miRNA strand is loaded into the RISC complex that typically includes Argonaut 1 (Ago-1).