Table 3.

Clinical outcomes during the 24-month post-discharge period following discharge from the index admission. Mortality and cumulative amputation rates are expressed from the day of the index procedure. Figures represent mean and (standard deviation) unless otherwise stated.

				$P$ value	$P$ value
	BIU	Top Ten	Rest of England	BIU vs.	BIU vs. Rest
Summary statistic	($n=$ 340)	($n=$ 2851)	($n=$ 24 666)	Top Ten	of England
Procedures
Mean number of osteomyelitis-related read-	0.24	0.56	0.66	0.0211	0.0140
missions per patient	(0.58)	(2.55)	(3.15)
Mean number of osteomyelitis procedures	0.23	0.57	0.63	0.0139	0.0137
in post-discharge period per patient	(0.59)	(2.54)	(2.99)
Mean number of osteomyelitis-related proce-	1.04	1.47	1.42	0.111	0.125
dure codes performed per patient	(2.81)	(4.87)	(4.56)
Amputation
Amputation rate in post-discharge period only (percentage of original cohort)	2.94 %	4.67 %	6.00 %	0.189	0.0244
Incidence rate of first amputation in post-	32.72	88.45	70.21	NR	NR
discharge period per 1000 patient years (95 % CI)	(21.33–50.18)	(80.49–97.20)	(67.78–72.75)
Cumulative total amputation rate during index admission and post-discharge period	6.47 %	15.96 %	12.71 %	$<$ 0.001	$<$ 0.001
Incidence rate of amputation occurring at any	32.72	88.45	70.21	NR	NR
time point per 1000 patient years (95 % CI)	(21.33–50.18)	(80.49–97.20)	(67.78–72.75)
Rate ratio of amputation occurring at any time	Reference	2.70	2.15	$<$ 0.001	0.001
(95 % CI)		(1.75–4.41)	(1.40–3.47)
Mortality in the post-discharge period
Mortality rate (percentage of original cohort)	4.71 %	20.06 %	22.63 %	$<$ 0.001	$<$ 0.001
Incidence rate of mortality per 1000 patient	24.29	112.73	128.72	NR	NR
years (95 % CI)	(14.88–69.66)	(103.80–122.43)	(125.34–132.19)
Mortality rate ratio (CI)	Reference	4.64	5.3	$<$ 0.001	$<$ 0.001
		(2.83–8.17)	(3.26–9.27)