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The effect miR-155-/- in animal models of systemic lupus erythematosus (SLE) and multiple sclerosis (MS). In MS the absence of miR-155 results in decreased number of Th1, Th17 and also decrement procution of IL-17, IL-6, TNF-α, and IFN-γ. In SLE, lack of miR-155 causes a marked reduction in Th1, Th17, Treg, B cells, and plasma cells.
