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. 2021 May 7;12:669382. doi: 10.3389/fimmu.2021.669382

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Copyright © 2021 Pashangzadeh, Motallebnezhad, Vafashoar, Khalvandi and Mojtabavi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miR-155 might have an important role in RA development. This miRNA activates Osteoclasts activation, Th17 cells, macrophages, and inflammatory cytokines, and blocks osteoblast production, and inhibitory cytokines, including IL-10. In addition, MMP production (especially MMP-1 and MMP-3) are decreaced through downregulation of IKBKE.