Table 2.
Distribution of allele frequency and P value of top four SNPs significantly associated with early-onset BPI disorder (≤20 years of age) in discovery and replication groups.
| SNP ID | CHR | BPa | Gene/Feature | Allele | Group | Minor allele frequency (%) | P | OR (95% CI) |
Pmeta(SAS)/ Pmeta(PLINK) |
|
|---|---|---|---|---|---|---|---|---|---|---|
| ≤20 | >20 | |||||||||
| rs75928006 | 19 | 54254388 | MIR522/upstream | C/T | Discovery | 9.4 | 3.9 | 6.45 × 10−9 | 2.58 (1.86, 3.60) |
9.23 × 10–8/ 8.14 × 10−5 |
| Replication | 15.7 | 16.7 | 0.7084 | 0.93 (0.64, 1.34) | ||||||
| rs11127876 | 3 | 85124697 | CADM2/intronic | C/T | Discovery | 9.3 | 4.1 | 7.04 × 10−8 | 2.39 (1.73, 3.31) |
5.19 × 10−8/ 1.26 × 10−7 |
| Replication | 21.2 | 15.6 | 0.0354 | 1.46 (1.03, 2.06) | ||||||
| rs7914868 | 10 | 16973722 | CUBN/intronic | C/G | Discovery | 12.4 | 6.3 | 7.59 × 10−8 | 2.10 (1.59, 2.76) |
7.00 × 10−7/ 8.31 × 10−6 |
| Replication | 24.5 | 22.5 | 0.5102 | 1.12 (0.81, 1.54) | ||||||
| rs10106565 | 8 | 8855032 | MFHAS1-ERI1/intergenic | C/T | Discovery | 9.8 | 4.5 | 9.70 × 10−8 | 2.31 (1.68, 3.16) |
1.33 × 10−7/ 4.38 × 10−5 |
| Replication | 18.6 | 17.8 | 0.7866 | 1.06 (0.74, 1.50) | ||||||
P values, ORs, and CIs were calculated based on the allele model.
OR odds ratio, CI confidence interval, Pmeta (SAS), Pmeta (PLINK) P value of meta-analysis generated by SAS and PLINK v. 1.9 program.
aLocation was cited according to GRCh37.p13.