Table 2.
Prior treatments.
| Glembatumumab vedotin (n = 218) | Capecitabine (n = 109) | All patients (n = 327) | ||||
|---|---|---|---|---|---|---|
| No. | % | No. | % | No. | % | |
| No. of prior cytotoxic-containing regimens in metastatic setting | ||||||
| Median | 1 | 1 | 1 | |||
| Rangea | 0–3 | 0–4 | 0–4 | |||
| No. of prior relapses in the advanced setting | ||||||
| 0 | 45 | 21 | 21 | 19 | 66 | 20 |
| 1 | 122 | 56 | 58 | 53 | 180 | 55 |
| 2 | 42 | 19 | 24 | 22 | 66 | 20 |
| 3 | 9 | 4 | 6 | 6 | 15 | 5 |
| Prior anthracycline | 185 | 85 | 95 | 87 | 280 | 86 |
| Prior taxane | ||||||
| No. of prior taxane therapies | ||||||
| 0 | 0 | 0 | 1 | 1 | 1 | <1 |
| 1 | 164 | 75 | 74 | 68 | 238 | 73 |
| 2 | 51 | 23 | 33 | 30 | 84 | 26 |
| ≥3 | 3 | 1 | 1 | 1 | 4 | 1 |
| Progression-free interval post taxaneb | ||||||
| ≤6 months | 112 | 51 | 51 | 47 | 163 | 50 |
| >6 months | 106 | 49 | 58 | 53 | 164 | 50 |
aProtocol eligibility required no more than two cytotoxic regimens in the advanced setting. There was one patient in each treatment arm that did deviate from this eligibility criteria.
bDetermined from the last taxane received.