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. 2021 May 20;12:2962. doi: 10.1038/s41467-021-23136-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Schematic representation of the hTopo IIα DNA-binding/cleavage domain. b Cryo-EM structure of the DNA-binding/cleavage domain in State 1 solved at 3.6 Å resolution. The structure is colored as in a, the DNA is colored in blue. c 2D classes of hTopo IIα in different orientations showing the flexibility of the ATPase domain. d EM density around the last coiled-coil helix and the CTD linker. e Zoom on the EM density of the etoposide and its binding site intercalating DNA bases +1 and −1.