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. 2021 May 20;12:2962. doi: 10.1038/s41467-021-23136-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Schematic representation of the hTopo IIα domains. Human Topo IIα is composed of two identical subunits assembling in an active homodimeric form. b Composite cryo-EM map of the full Human Topo IIα with DNA-gate in closed state. c 3D and 2D classes showing the flexibility and motions of the ATPase domain with respect to the DNA-binding/cleavage domain. d Atomic model of the full-length Human Topo IIα. The structure is colored as in a, the DNA is colored in blue.