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. 2021 May 20;12:2977. doi: 10.1038/s41467-021-23260-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Top left, depiction of the virtual reality (VR) setup. Top right, the familiar (F) and two novel (N1 and N2) environments. Bottom: scheme of the experimental procedure. b Top: single mouse behavior showing track position versus time during an F to N switch. Bottom: summary data across all mice of mean lap velocity during F and N (n = 20 sessions in 11 mice). Lap velocity is normalized to the mean lap velocity in each mouse ±SEM, and each lap is compared to the first lap in F using a one-way ANOVA with Tukey HSD post hoc test. ***P < 0.001, P = 6.3 × 10⁻¹⁵. c Brain slice showing specific CA3 expression of cre-dependent GCaMP6f (green) and DAPI for nuclei (blue) from a Grik4-cre transgenic mouse. d Example field of views (FOV) from multiplane imaging in CA1 (top) and CA3 (bottom). Right: scheme of the position for the objective during imaging.