Table 1.
Summary relative risks and 95% confidence intervals for the association between primary sclerosing cholangitis and cancer and all-cause mortality.
| Outcome | N | Cases | Participants | RR (95% CI) | I2 | Pheterogeneity | Egger | References |
|---|---|---|---|---|---|---|---|---|
| Cholangiocarcinoma | 4 | 92 | 1582 | 584.37 (269.42–1267.51) | 89% | < 0.0001 | 0.15 | 10–13 |
| Hepatobiliary cancer | 3 | 46 | 2720 | 155.54 (125.34–193.02) | 0% | 0.47 | 0.67 | 11,14,15 |
| Liver cancer | 2 | 56 | 1236 | 30.22 (11.99–76.17) | 0 | 0.49 | – | 2,13 |
| Gastrointestinal cancer | 4 | 115 | 3421 | 16.92 (8.73–32.78) | 87.7 | < 0.0001 | 0.22 | 2,11,14,16 |
| Pancreatic cancer | 3 | 15 | 2736 | 7.56 (2.42–23.62) | 28.6% | 0.25 | 0.42 | 13,14,17 |
| Colorectal cancer | 7 | 71 | 3774 | 6.10 (4.19–8.87) | 14.0 | 0.32 | 0.17 | 11–15,17,18 |
| Total cancer | 5 | 336 | 3956 | 4.13 (2.99–5.71) | 80.3 | < 0.0001 | 0.44 | 2,11,13–15 |
| All-cause mortality | 5 | 477 | 3942 | 3.55 (2.94–4.28) | 45.7 | 0.12 | 0.68 | 2,11–13,15 |
| Cardiovascular disease | 2 | 971 | 7106 | 1.57 (0.25–9.69) | 79.4 | 0.03 | – | 15,19 |