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. 2021 May 20;12(6):515. doi: 10.1038/s41419-021-03801-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Scheme of the experimental procedure and monitoring of intramuscular carcinogenic induction mediated by 3MC in murine models of Emx1 and Emx2. Each cohort comprised 15 mice. B, C Graph of the days since the first tumor sign in each cohort of Emx1 (B) and Emx2 (C). F, G Survival curve with respect to time post treatment with 3MC in Emx1 (F) and Emx2 (G). D, E Representative photographs of the control and tumor limbs of each Emx1 (D) and Emx2 (E) cohort. The p-value of the survival graphs was obtained using the LogRank test. The rest of the analysis was performed with Student’s t-test (*p < 0.05; **p < 0.01; ***p < 0.001). H–J Effect of Emx1 or Emx2 depletion on the tumor invasiveness of the bone marrow of the femur in the 3MC-induced sarcomas. In H, representative micrographs of the three grades into which the evolution of the tumor infiltration of sarcoma induced by 3MC in the bone marrow has been divided with respect to the control tissue. The points of initiation or progression of the infiltration are highlighted with the arrowhead. The bar indicates 200 µm. I, J Graphs of the degree of tumor infiltration measured in the Emx1 (I) and Emx2 (J) KO line cohorts. Each cohort had 15 mice. Statistical analysis was performed with Student’s t-test (*p < 0.05; **p < 0.01; ***p < 0.001).