Fig. 5. Whole-body fluorescent imaging of Medaka larvae.
a Three-dimensional reconstructed view of the lymphatic and blood vessels in the whole body of a 2 wph larva. Green shows the EGFP signals from the FLT4-EGFP transgenic strain, and red shows the dextran-conjugated rhodamine signals from the blood vessel. The yellow rectangular shows a magnification view at the body trunk. Exposure time is 100 ms, z-interval is 2 μm, and xy 1024 × 1024 pixels. n = 3 biologically independent larvae are subjected to the analysis. b Three-dimensional reconstructed view (left) and a sliced view (right) of the whole brain of the Kif5Aa-EGFP strain larva. Exposure time, z-interval, and xy are 100 ms, 2 μm, and 1024 × 1024 pixels, respectively. n = 5 biologically independent larvae are subjected to the analysis. Abbreviations; DA dorsal aorta, DL dorsal lymphatic, DLAV dorsal longitudinal anastomotic vessel, LL lateral lymphatic, PCV posterior cardinal vein, SL spinal lymphatic.