Table 1.
Radioligand binding parameters in the prefrontal cortex of subjects with schizophrenia and matched controls.
| Schizophrenia | Control | F[d.f.,d.f.] | p Value | |||||
|---|---|---|---|---|---|---|---|---|
| Bmax (fmol/mg) | Kd (nM) | n | Bmax (fmol/mg) | Kd (nM) | n | |||
| Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | |||||
| [18F]Altanserin | 352 ± 15 | 0.32 ± 0.05 | 20 | 410 ± 17 | 0.32 ± 0.05 | 20 | F[1,288] = 6.361 | 0.0122 |
| [3H]LSD | 765 ± 47 | 1.5 ± 0.32 | 20 | 640 ± 23 | 0.73 ± 0.11 | 20 | F[1,311] = 8.282 | 0.0043 |
| [3H]MDL100907 | 324 ± 23 | 0.29 ± 0.07 | 20 | 335 ± 16 | 0.28 ± 0.04 | 20 | F[1,294] = 0.354 | 0.7023 |
For each radioligand, the two sets of data (schizophrenia and control) were first analysed separately. The overall value for the sum of squares and the degrees of freedom (d.f.) was the sum of the individual values of each fit. Next, the two sets of data were pooled and analysed simultaneously constraining them to share one or two common parameters (Bmax, Kd). The pooled fit yielded values for the sum of squares and degrees of freedom. The analysis that permitted one or two parameters to be shared without a significant increase in the residual variance was taken as the best fit. [18F]Altanserin and [3H]LSD binding curves were considered different between schizophrenia and control. The subsequent analysis demonstrated that statistical differences were adscribed to different Bmax but not to Kd values. The F, d.f. and p values displayed correspond to this condition. For [3H]MDL100907, estimations obtained under equivalent analysis are shown.