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. 2021 May 7;15:657507. doi: 10.3389/fnins.2021.657507

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Copyright © 2021 Zhang, Feng, Pei, Zhang, Chen, Wei, Zhou, Yong and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of electroacupuncture (EA) on mechanical allodynia induced by chronic constrictive injury (CCI) in Sprague-Dawley (SD) rats. EA treatment was applied at day 8 after CCI. The rats received EA stimulation once every other day for 8–28 days (total of 11 times). Evaluations of mechanical withdrawal thresholds in the sham group, CCI-induced neuropathic pain (NeuP) model group (CCI group), and CCI-induced NeuP model with EA treatment group (EA group). All data are expressed as the mean ± SEM (n = 13 per group). **p < 0.01, ***p < 0.001 vs. the sham group; ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 vs. the CCI group.