Figure 2.

Life Cycle of the Coronaviruses. Coronaviruses particles bind to ACE2 receptor. TMPRSS2 promote viral uptake and fusion at the cellular or endosomal membrane. Following entry, the release and uncoating of the genomic RNA subject it to the immediate translation of the two large open reading frames, ORF1a, and ORF1b. During the cellular life cycle, coronaviruses express and replicate their genomic RNA to produce full-length copies that are incorporated into newly produced viral particles (8).