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. 2021 May 7;11:678474. doi: 10.3389/fonc.2021.678474

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Copyright © 2021 Lv, Lv, Yang, Qi, Wang, Li, Shang, Guo, Zhang and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Downregulation of lncRNA SNHG6 regulates miR-125b-5p/BMPR1B signaling pathway in TNBC cells. (A) Predicted binding sites between lncRNA SNHG6 and miR-125b-5p. (B) Dual-luciferase reporter assay verified the presence of a direct binding site between miR-125b-5p and lncRNA SNHG6. (C) Knockdown of SNHG6 upregulated miR-125b-5p expression in MDA-MB-231 and BT-549 cells. (D) Predicted binding sites between miR-125b-5p and BMPR1B. (E) Dual-luciferase reporter assay verified the presence of a shared binding site between miR-125b-5p and BMPR1B. (F) miR-125b-5p inhibition upregulated BMPR1B mRNA expression. (G) miR-125b-5p inhibition upregulated BMPR1B protein expression. (H) miR-125b-5p inhibition attenuated the impact of lncRNA SNHG6 suppression on BMPR1B mRNA expression. (I) miR-125b-5p inhibition attenuated the impact of lncRNA SNHG6 suppression on BMPR1B protein levels. *P < 0.05, ** P < 0.01, *** P < 0.001; n = 3.