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. 2021 May 20;12(6):517. doi: 10.1038/s41419-021-03782-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — A–C Photography of xenograft tumor-bearing mice injected with different cell lines transfected. D, E Tumor volume and tumor weight for each group. F–I Expression of TSP50 and PKM2, lactate production and ATP levels were detected in tumor. J–L Photography of xenograft tumor-bearing mice injected with different cell lines transfected. M, N Tumor volume and tumor weight for each group. O–R Expression of TSP50 and PKM2, lactate production and ATP levels were detected in tumor. n = 6 in each group. All aerobic glycolysis values were normalized to protein levels. N = 3 biologically independent replicates. t-Test or one-way ANOVA statistical analysis was used. Data were presented as means ± s.d. *P < 0.05, **P < 0.01. ns, no significance.