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. 2021 May 20;10(5):43. doi: 10.1038/s41389-021-00330-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A In vivo imaging was performed to evaluate the tumor burden in mice of shPSMC2 and shCtrl groups at day 37 post-tumor-inoculation. B The fluorescence intensity was scanned and used as a representation of tumor burden in mice of shPSMC2 and shCtrl groups. C 12 days post-injection of GBC-SD cells with or without PSMC2 knockdown, the volume of tumors formed in mice was measured and calculated at indicated time intervals. D Mice were sacrificed at day 37 post-injection, and the tumors were removed for collecting photos (inset of C) and weighing. E After removing the tumors, the Ki67 index was evaluated by IHC staining as a representative of tumor growth activity. F The expression of Akt, p-Akt, CDK6, Cyclin D1, and MAPK9 was detected by western blotting in GBC-SD cells with or without PSMC2 knockdown. Data were shown as mean ± SD. *P < 0.05, ***P < 0.001.