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. 2021 May 7;15:634063. doi: 10.3389/fnins.2021.634063

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Copyright © 2021 Oladosu, Liu, Pike, Koch, Metz and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regions of interest development. (A) An example lesion region of interest (ROI) in the T1- FLAIR MRI space (purple mask); (B) A mirror-image of the T1-weighted MRI for developing the contralateral normal appearing white matter (NAWM) ROI (green mask) of the lesion shown in panel A; (C) the finalized contralateral NAWM ROI of the lesion produced using (panel A, B), along with converse co-registration between the corresponding image volumes; the blue and purple areas within the lesion represents the core and shell ROIs, respectively; and (D) 3D whole brain lesion masks produced by grouping adjacent ROI voxels within and between slices.