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. 2021 May 7;15:634063. doi: 10.3389/fnins.2021.634063

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Copyright © 2021 Oladosu, Liu, Pike, Koch, Metz and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Example lesion regions and top diffusion metrics identified in the tissue separation processes. Shown are diagrams for a whole lesion (black, top) and a core-shell lesion (white and black, bottom) used for the lesion versus NAWM and core versus shell classifications, as well as corresponding appearances in the T1-weighted and FLAIR MRI (columns 1–3). The other columns (4–6) demonstrate the top three diffusion features selected by the recursive feature elimination algorithm (SVM-RFE) in respective classification tasks, which are orientation distribution function energy, fractional anisotropy, and orientation dispersion index (top); and mean diffusivity, radial diffusivity, and fractional anisotropy (bottom).