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. 2021 May 7;9:665813. doi: 10.3389/fcell.2021.665813

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Copyright © 2021 Tang, Liu, Liu, Yu, Wang, Tan and Ye.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Formation of the polymer network from HEMA and DMAEDA via Michael addition reaction (purple arrows: positive charges of DMAEMA). (B) In situ self-assembly of CaP NPs around -COOH group of PGA via -COO^– -Ca²⁺ coordination. (C) The interaction between the PGA and the polymer network via electrostatic attraction. Reproduced from ref. Kuang et al. (2019) with permission from the American Chemical Society (Copyright 2019).