Table 5.
Predictive factors for higher grade final histology
| Risk factors | Higher grade final histology (n=11) | Low grade final histology (NEH or no residual hyperplasia, n=37) | Odds ratio | 95% confidence interval | P-value |
|---|---|---|---|---|---|
| Age (yr) | 51.6±8.7 | 50.7±6.9 | 0.72 | ||
| Menopausal | |||||
| No | 6 (54.5) | 26 (70.3) | 1 | - | - |
| Yes | 5 (45.5) | 11 (29.7) | 0.51 | 0.13–2.0 | 0.34 |
| Parity | |||||
| Median | 1 | 2 | - | - | 0.039 |
| 0 | 5 (45.5) | 7 (18.9) | 5.24 | 0.99–27.69 | 0.051 |
| 1 | 3 (27.3) | 8 (21.6) | 2.75 | 0.46–16.53 | 0.269 |
| ≥2 | 3 (27.3) | 22 (59.5) | 1 | Reference | - |
| BMI (kg/m2) | |||||
| Mean | 30.1±6.5 | 25.9±5.3 | - | - | 0.033 |
| <30 | 5 (45.5) | 32 (86.5) | 1 | Reference | - |
| ≥30 | 6 (54.5) | 5 (13.5) | 7.68 | 1.69–34.96 | 0.008 |
| Diabetes mellitus | |||||
| No | 8 (72.7) | 31 (83.8) | 1 | Reference | - |
| Yes | 3 (27.3) | 6 (16.2) | 1.94 | 0.40–9.49 | 0.42 |
| Use of tamoxifen | 2 (18.2) | 1 (2.7) | - | - | 0.092 |
| Clinical presentation and characteristics | |||||
| Thickened endometrium on ultrasound | 6 (54.5) | 15 (40.5) | 0.41 | ||
| Thickened endometrium on hysteroscopy | 8 (72.7) | 16 (43.2) | 0.086 | ||
| D&C hysteroscopy done by trainee | 7 (63.6) | 23 (62.2) | 0.93 | ||
| Initial histology with complex NEH | 9 (81.8) | 30 (81.1) | 0.95 | ||
| Time to surgery (days) | 87.7±31.0 | 73.9±36.7 | 0.26 | ||
| Use of progestin therapy before surgery | 6 (54.5) | 17 (45.9) | 0.62 |
Values are presented as mean±standard deviation or number (%).
NEH, non-atypical endometrial hyperplasia; BMI, body mass index; D&C, dilation and curettage.