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. 2021 May 21;12:297. doi: 10.1186/s13287-021-02378-7

Fig. 3.

Fig. 3

Extracellular vesicle (EVs) biogenesis. Exosomes are smaller luminal vesicles (30100nm in diameter) crated from late endosomes that are shaped by inward budding of the limited multivesicular body (MVB) membrane; however, microvesicles (MVs) are small membrane vesicles (0.11m in diameter) secreted from the cell membrane surface. The content, or cargo, of EVs, includes lipids, nucleic acids, and proteins, in particular, proteins related to the plasma membrane, cytosol, and those that participated in lipid metabolism